At Abhidharmakośa VI .3, Vasubandhu analyses the phrase sandhāya ... bha $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{s} $$ ita $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{m} $$ as used in the sūtras. Here bhā $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{s} $$ ita $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{m} $$ mentions an utterance, to which a figurative sense is ascribed by the gerundive (not noun) sandhāya. The audience is split: some are intended to understand the literal, others the figurative sense. Vasubandhu's analysis works well for sandhābhā $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{s} $$ a etc. in the Saddharmapu $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{n}$$ $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{d}$$ arīka and the Guhyasamājatantra. (The Hevajratantra is (...) different and we consider it separately). Poussin's “arrière-pensée”, Edgerton's “real meaning” and “esoteric meaning”, and Wayman's “twilight language” are attractive in some cases but not all. Vasubandhu's analysis combined with Edgerton's “specially intended” (for ābhiprāyika) is much better; compare V. S. Bhattacharya's old paraphrase of this word “intended to imply or suggest something different from what is expressed by the words”. But Bhattacharya's widely accepted translation “intentional” for ābhiprāyika is misleading and misrepresents Vasubandhu, and we suggest ways of improving it in the light of the need for coherent translation, with the help of some considerations from Pā $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{n}$$ ini and from Montague semantics. (shrink)

In November of 2019, the University of California Santa Cruz hosted a 3-day interdisciplinary conference to commemorate the 200th anniversary of the publication of Frankenstein, by Mary Shelley. A panel of senior researchers convened to discuss the impact of the novel on modern discussions of scientific ethics. The panel featured Nandini Bhattacharya, George Blumenthal, Michael M. Chemers, David Haussler, and Jenny Reardon. In the process, the panelists acted as the Institutional Review Board for a proposal from Victor Frankenstein himself.

Now, in Emergent Forms of Life and the Anthropological Voice, path-breaking scholar Michael M. J. Fischer moves the discussion to a consideration of the ...

Volume 19, Issue 5, May 2019, Page 24-26.

The fair innings argument (FIA) is frequently put forward as a justification for denying elderly patients treatment when they are in competition with younger patients and resources are scarce. In this paper I will examine some arguments that are used to support the FIA. My conclusion will be that they do not stand up to scrutiny and therefore, the FIA should not be used to justify the denial of treatment to elderly patients, or to support rationing of health care by (...) age.There are six issues arising out of the FIA which are to be addressed. First, the implication that there is such a thing as a fair share of life. Second, whether it makes sense to talk of a fair share of resources in the context of health care and the FIA. Third, that 'fairness' is usually only mentioned with regard to the length of a person's life, and not to any other aspect of it. Fourth, if it is sensible to discuss the merits of the FIA without taking account of the 'all other things being equal' argument. Fifth, the difference between what is unfair and what is unfortunate. Finally, that it is tragic if a young person dies, but only unfortunate if an elderly person does. (shrink)

This paper provides a detailed account of the origins of the Psycho logical Review in 1894, of the policies and practices of its editors (James Mark Baldwin and James McKeen Cattell) during its first decade, and of the public and private disagreements that led them to dissolve their collaboration in 1904. In doing so, it sheds light on the significant roles played by specialized scientific journals in the development of specific scientific specialities, and illustrates the value for historical exploration of (...) (what anthropologists call) a 'thick description' of (what historians call) 'the fine texture of the past'. It argues that personal factors such as luck and character and temperament often have a greater impact on the way in which science actually evolves than do intellectual interests and concerns, and concludes with an analysis of the overwhelming signifi cance of this episode on the later careers of both Baldwin and Cattell. (shrink)

Williams James’s 1903 election to the National Academy of Sciences has long been understood as well-deserved recognition for his scientific achievement and as evidence that other sciences had begun to accept the “new psychology” as a peer discipline. This note offers a detailed review of the complex course of events that led to James’s election – presented within the context of the Academy’s own history – that illustrates just how a variety of extra-scientific factors had a significant impact on this (...) tribute. It closes with a review of James’s own activities as an Academy member. (shrink)

The essay is a response to an invitation to offer reflections on Richard Lennan’s recent book Tilling the Church for a panel at the annual gathering of the Karl Rahner Society. It situates the work within the distinctive spiritual and intellectual heritage shared by Karl Rahner, Pope Francis, and Lennan’s scholarly community and vocational home at Boston College, namely by reading it through an intentionally Ignatian lens. The review overlays the volume’s ecclesiological explorations with reference to the Spiritual Exercises and (...) to the contours of the current emphasis or re-emergence of the Ignatian tradition on a global stage given the last eleven years and the unique pulpit they provide via the Petrine Office. The piece argues that the adaptability and flexibility of the Ignatian heritage finds profound and lasting resonance with Lennan’s recent project and hopeful agenda. (shrink)

This paper surveys the meaning of aither in Empedocles. Since Aristotle, Empedoclean aither has been generally considered synonymous with air and understood anachronistically in terms of its Aristotelian conception as hot and wet. In critiquing this interpretation, the paper first examines the meaning of “air” in Empedocles, revealing scant and insignificant use of the term. Next, the ancient controversy of Empedocles’ “four roots” is recast from the perspective that aither, rather than air, designates the fourth root. Finally, the nineteen instances (...) of aither in Empedocles’ fragments are considered, revealing a bright and energetic root closely related to the force of life. (shrink)

Physician assisted suicide or active euthanasia is analyzed as a medicalization of the needs of persons who are suffering interminably. As with other medicalized responses to personal needs, the availability of active euthanasia will likely divert attention and resources from difficult social and personal aspects of the needs of dying and suffering persons, continuing the pattern of privatization of the costs of caregiving for persons who are candidates for active euthanasia, limiting the ability of caregivers to assist suffering persons to (...) make their continued suffering tolerable, and casting doubt on the voluntariness of the choice of active euthanasia. Keywords: caregivers, euthanasia, family, medicalization, voluntariness CiteULike Connotea Del.icio.us What's this? (shrink)

Previous research shows that students often do not read informed consent forms to understand their rights. Four hundred fifty-eight students participated in an advertised temperament study that actually measured whether they noticed a manipulation within the consent form. Answering five questions about the form raised the percentage of students noticing the manipulation in multiple settings; however, overall rates were low. Fewer than 10% of ethnic minority students noticed the manipulation. If the goal of consent forms in higher education remains an (...) informed decision, these results indicate the need for increased interaction within the consent process. (shrink)

In this article, I examine Thomas Aquinas's teaching on the light of glory (lumen gloriae), and attempt to resolve several problems that arise within this teaching.

The archive is the place for the storage of documents and records. With the emergence of the modern state, it became the storehouse for the material from which national memories were constructed. Archives also housed the proliferation of files and case histories as populations were subjected to disciplinary power and surveillance. Behind all scholarly research stands the archive. The ultimate plausibility of a piece of research depends on the grounds, the sources, from which the account is extracted and compiled. An (...) expanding and unstable globalizing archive presents particular problems for classifying and legitimating knowledge. Increasingly the boundaries between the archive and everyday life become blurred through digital recording and storage technologies. Not only does the volume of recordable archive material increase dramatically (e.g. the Internet), but the volume of material seen worthy of archiving increases too, as the criteria of what can, or should be, archived expands. Life increasingly becomes lived in the shadow of the archive. (shrink)

In Michael Stingl argues that the legalization of euthanasia can be made reasonable social policy only in the context of healthcare reform to deliver primary- and community-based care. Stingl accepts that euthanasia and that includes not only pain, but He is not worried The failure of the healthcare system to adequately respond to the needs of people who are suffering with chronic or terminal conditions may lead competent people to elect euthanasia. Stingl argues that it is the institutionalization of (...) care for dying people that reduces their ability to find meaning in prolonged life, and thereby makes it more attractive to consider ending one's life sooner. Options such as palliative care at home that significantly improve quality of life and make euthanasia less attractive are currently only available to those who can privately subsidize healthcare services. If an emphasis is placed on community-based initiatives and well-supported self-help, then there would be less inequality of healthcare and the voluntariness of choices, including euthanasia, would be more equal for all people under the healthcare system. (shrink)

Many viral and cellular mRNA species contain a leader sequence derived from a distant upstream site on the same gene by a process of RNA splicing. This process usually involves either nuclear functions or self‐splicing of RNA molecules. Coronavirus, a cytoplasmic RNA virus, unfolds yet another mechanism of joining RNA, which involves the use of a free leader RNA molecule. This molecule is synthesized and dissociates from the template RNA, and subsequently reassociates with the template RNA at down‐stream initiation sites (...) of subgenomic mRNAs to serve as the primer for transcription. This leader‐primed transcriptional process thus generates viral mRNAs with a fused leader sequence. A similar mechanism might also operate in the mRNA transcription of African trypanosomes. (shrink)

Why do people think that someone living a morally bad life is less happy than someone living a good life? One possibility is that judging whether someone is happy involves not only attributing positive psychological states (i.e., lots of pleasant emotions, few unpleasant emotions, and satisfaction with life) but also forming an evaluative judgment. Another possibility is that moral considerations affect happiness attributions because they tacitly influence attributions of positive psychological states. In two studies, we found strong support for the (...) second hypothesis. Moral considerations only appear to affect happiness attributions when they also affect attributions of positive psychological states. Additionally, both studies supported a hypothesis about why moral judgments have these effects. Specifically, we found that when people judge that someone is living a bad life, they infer that the person is not at peace with themselves. However, when this inference is blocked, moral considerations do not affect attributions of happiness or positive psychological states. In sum, although “happiness” appears to be a purely psychological concept, happiness judgments are sensitive to moral considerations because people often assume that immorality disrupts intrapersonal harmony. (shrink)

Betrifft die Handschriften Codd. 12, 13 (S. 185), 134 (S. 181, 332, 336-337), 224 (S. 173), 325 (S. 246), 352 (S. 185), 540 (S. 113, 211) und A 91.8 (S. 2-3, 168, 177, 320, 328, 354) der Burgerbibliothek Bern.

This book declares that lifelong learning teaches values and wholeness and rejects inert ideas or fragmentation. Education plays a vital role in reorganizing and revitalizing the abundant facts from the information explosion. Specialization works at cross-purposes with liberal arts education, which discloses a holistic vision of each person's being.

Significant progress has been made over the last decade in elucidating the mechanisms employed by receptor protein tyrosine kinases (RTKs) in transducing extracellular signals critical for the regulation of diverse cellular activities. Nevertheless, revealing the biological significance of a subset of the RTKs that contain catalytically inactive protein tyrosine kinase domains has proven more elusive. ErbB3 has served as the prototype for models of catalytically inactive RTK function, performing the role of signal diversification in heterodimeric receptor complexes with other ErbB (...) subfamily members. The receptor related to tyrosine kinases (RYK) is unique amongst the catalytically inactive RTKs. Based on structural or functional properties of the extracellular domain, RYK cannot be classified into an existing RTK subfamily. Recent genetic analyses of mouse Ryk and its Drosophila orthologue derailed have defined a role for this novel subfamily of receptors in the control of craniofacial development and neuronal pathway selection, respectively. Recent biochemical data lead us to propose a model that involves RYK in signal crosstalk and scaffold assembly with Eph receptors. This model is consistent with the established roles of Eph receptors and ephrins in craniofacial and nervous system morphogenesis. BioEssays 23:34–45, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Alfred Schutz’ article on the well-informed citizen can, among others, also be read as a treatise on the information flow in democratic society. To be “well-informed” is a challenge the citizen has to keep up with in order to play his role in civil society, and being well-informed is also to be seen as a precondition for a fairly functioning political community. For Jürgen Habermas, it is the free press that guarantees public communication of democratic societies and which is threatened (...) by the colonisation of the life-world by system constraints following capitalistic logic. The systems nowadays threatening the life-world have additionally become digital in nature, questioning the traditional division of public and private, whereby the challenge of the well-informed citizen set up by Schütz has not lost any relevance nor contemporary interest. On the basis of Schutz’ framework, these questions are debated in the context of Habermas’ Structural Change of the Public Sphere, Volker Gerhardt’s theory of the Public Sphere, and Vilém Flusser’s analyses of the new telematic digitalized society. (shrink)

This paper examines a proposal to make use of IVF techniques to provide an alternative to therapeutic abortion of fetuses with genetic abnormalities. We begin by describing the proposed procedure, and then show that, considered in itself, it is morally on a par with therapeutic abortion. However, once the wider practical implications are brought into view, the proposed new procedure loses its initial appeal. The pros and cons are not sufficiently clear-cut entirely to rule out the IVF procedure, so the (...) paper concludes by indicating some further complications which may follow, should the procedure come to be adopted. (shrink)

ABSTRACTThere is surprisingly little empirical evidence supporting theoretical and anecdotal claims regarding the spontaneous production of prototypic facial expressions used in numerous emotion re...

The multiple activities of the RecA protein in DNA metabolism have inspired over a decade of research in dozens of laboratories around the world. This effort has nevertheless failed to yield an understanding of the mechanism of several RecA protein‐mediated processes, the DNA strand exchange reactions prominent among them. The major factors impeding progress are the invalid constraints placed upon the problem by attempting to understand RecA protein‐mediated DNA strand exchange within the context of an inappropriate biological paradigm – namely, (...) homologous genetic recombination as a mechanism for generating genetic diversity. In this essay I summarize genetic and biochemical data demonstrating that RecA protein evolved as the central component of a recombinational DNA repair system, with the generation of genetic diversity being a sometimes useful byproduct, and review the major in vitro activities of RecA protein from a repair perspective. While models proposed for both recombination and recombinational repair often make use of DNA strand cleavage and transfer steps that appear to be quite similar, the molecular and thermodynamic requirements of the two processes are very different. The recombinational repair function provides a much more logical and informative framework for thinking about the biochemical properties of RecA and the strand exchange reactions it facilitates. (shrink)

Some decades before Umberto Eco refounded semiotics in the sixties, Alfred Schutz had already elaborated a theory on signs and symbols. Moreover, as Schutz himself affirms, neither was he the first to do so. The thoughts of Charles Sanders Peirce had already clearly influenced American pragmatism, and thinkers like George Herbert Mead and Ernst Cassirer had developed a theory of symbols, both referred to by Schutz in his later works. Nonetheless, sign theory was already present in his first book, Der (...) sinnhafte Aufbau der sozialen Welt, and can be traced to the influence of Edmund Husserl. Schutz’s focus on the analysis of the relationship between individual and society fomented his perception of the importance of intermediary communication and sign processes as the setting and interpretation of signs, “Zeichensetzung und Zeichendeutung”, reflections that in his later working phase resulted in a proper sign theory, which is analyzed in the following article. Based on Husserl’s concept of pairing, Schutz here develops his theory of appresentational references, comprising a subdivision of: marks, indications, signs and symbols. This involves the concept of representation, a relationship between the signifier and the signified, and a subjective as well as constructive interpretation by actors. Consequently, this concept involves an objective sign system, a social situation and, as inserted into a process of communication, complementary producers and receptors of signs and symbols. In the final comments the question is addressed whether, and in what sense, given the preceding theory of appresentational references, Schutz would hold that reality is a symbolic construction, as proposes the title of the 2016 conference on Schutz in Tokyo, The Symbolic Construction of Reality. (shrink)

This paper examines parataxis and ring composition in Anaxagoras Fragment B4a, arguing that this ostensibly prose philosopher employs these poetic techniques to capture his thought. Comparing the fragment with Homeric similes and his description of Achilles’s Shield from Ililad XVIII reveals an immanent poetics within the Anaxagorean text. Lying between two instances of "πολλά τε καὶ παντοῖα" (many things of all kinds) most of fragment constitutes a single sentence. Such ring composition advises that no part of the paratactic clause should (...) be read independently from any other. This supports reading the discussion of "seeds" (σπέρματα) and "compacted" (συμπαγῆναι) human beings in B4a as yielding a conception of infinitely proliferating microcosmic worlds each undergoing its own separation within a single cosmos. (shrink)

This project reframes the four roots (or elements) in Empedocles in order to challenge the Aristotelian account of the One as undifferentiated sameness. Aristotle credits Empedocles with developing both the theory of four material elements and introducing the conception of dualistic moving causes into philosophy through Love and Strife. Aristotle’s interpretation maintains a singular moment in the evolution of the cosmos when Love dominates the whole and unifies all things into a perfectly spherical One, which he describes as an undifferentiated, (...) qualityless substratum. Based on Fragments B17, B62, and B110, this paper argues that a rhizomatic motion in which each root tends towards its own kind emerges from the roots independently of Love and Strife. Thus, Empedocles actually maintains three different sorts of motion: (1) the motion of unlike towards unlike, motivated by Love, (2) the motion of unlike away from unlike, motivated by Strife, and (3) a rhizomatic motion of like to like. The presence of six sources of motion challenges Aristotle’s assumption that, as the One, the universe enjoys a moment of identity without difference. The presence of rhizomatic motion makes the blending or mixing of the roots impossible in the Σφαῖρος. The paper begins by developing Aristotle’s paradox of Strife in the Metaphysics and his paradox of alteration in On Generation and Corruption, followed by Empedocles’ account of mixture and separation in Fragments B8 and B35. Section three examines the precise functions of Love and Strife in Fragments B17 and B21. The last section considers the Empedoclean Σφαῖρος under these different conditions, arguing that the cosmic sphere should not be viewed as an inconsistent disappearance of the roots, but as god understood as a singular community of difference. (shrink)